Combination of organic acids.



UNITED PAT nroFFIoE. v.

ALEX ."B; DAVIS, F INDIANAPOLIS,

INDIANA; AssIeNoR To one m main];

c oMeA'nY, or mmANAPoL Is, INDIANA. A co troRATmNjOEmDmnA;

COMBINATION or oRG mc' cxnsl No Drawing;

To aZZwhom it may concern: I Be it known that I, 'ALEX BI DAVIS, 'a citizen of the United States, residing at Jndianapolis,lVIarion county, and State,- of- 5 Indiana, have invented and discovered certain new and useful Improvements in Conibinations of Organic Acids, of which the following is'a specification.

My invention relates toa combination of 2-phenyl-quinolin-4-carboxylic acid and salicy'lic acid. The compound isa useful thera} peutic agent. t

The preparation, of the compound is car-' ried out as follows :249 partsiby weight I vim- 09i i completely masked by the combination.

' The compound is insoluble in ivfater, slightly 2. A molecular compound of .2-phenylv 40 quinolin -e carboxylic acid and salicylic acid. 3. The processofproducing combinatlons of 2-phenyl-quino1in-etwarboxylic acid and salicylic acid by precipitating mixed'solutions of their salts with mineral acids.

amass ofyellow- The compound is nearly tasteless; the 30 a'crid taste of the salicylic acid being almost fi fi of L t Patentratenteaoca-si,1916; Application filed m 1.91s. Seria1 No. 11,9 07

of 2 phenyl-quinolin-4-carboxylic acid iii-e dissolved in gin-alkaline solution preferably 4 a solutionof 42* parts of caustic soda in 1000 parts of-water' and '"o tlis, 160 parts of sodiumtsalicylate are. =ddt is Then the s'odiuin salicylate has dissolvedjthe solution"20-' is chilledi by the-addition of. a small amount of-cracked ice and 200 parts of concentrated. hydrochloricacidare added. 'A sticky 'y'ellowmass precipitates and soonso'lidifi'es'to tals'; the cry tallization y; stirring; rapidly. This V v, a-"molecular compound of.

maybe hastene mass is probabl the two acids, of the'formula v 4. The process which consists in. adding to a solution of the alkali salts of 2i-phenylquinolin-l-carboxylic acid and sa lieylficiacid, in equimolecular proportion, amin e'ralacid, and thereby precipitating a body containinj the 2qa'lienyl quinolin-i-carboxylic acid-and. salicylicacid. T 1' Y In witness whereof," I have hereunto set ,mV' hand and. seal at lndianapolislndiana,

this21st "day of.- July, A.. D. nineteen hundred anc'lfifteenl- I iLnxn-navis "[1. 8.1-: Witnesses:

--A. 'C.RIcE,, 

